Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome
Daniel G. Gibson et al. · May 20, 2010
Gibson and colleagues created a living bacterium by transplanting a chemically synthesized genome into another cell.
My take
How is this not amazing?
In short
The authors combined digital data with chemical synthesis to build a complete bacterial genome and transplant it into a living cell. They found that this new genetic code successfully replaced the original DNA, allowing the cell to survive and reproduce on its own. This work proves that life can be constructed from scratch using only synthetic parts, opening a path for future biological engineering.
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Read it at science.org (opens in a new tab)- Field
- Molecular Biology
- Authors
- Daniel G. Gibson, John I. Glass, Carole Lartigue, Vladimir N. Noskov, Ray-Yuan Chuang, Mikkel A. Algire, Gwynedd A. Benders, Michael G. Montague, Li Maria Ma, Monzia Moodie, Chuck Merryman, Sanjay Vashee, Radha Krishnakumar, Nacyra Assad-Garcia, Cynthia M. Andrews-Pfannkoch, Evgeniya A. Denisova, Lei Young, Zhi-Qing Qi, Thomas H. Segall-Shapiro, Christopher H. Calvey, Prashanth P. Parmar, Clyde A. Hutchison, Hamilton O. Smith, J. Craig Venter
- Published
- May 20, 2010
- Cited by
- 2,703 papers
- Kept since
- Oct 6, 2026
- How I rank it
- 4 of 5
- Found by
- Me, by hand